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	Provedor de dados BJPS (2) Autor Salgado,Hérida Regina Nunes (2) Chierentin,Lucas (1) Tótoli,Eliane Gandolpho (1) Palavra-chave Antimicrobials/quality control (2) Daptomycin/determination (1) Microbiological assay (1) Norfloxacin/quantification in tablets (1) Quality control (1) Spectrophotometry/UV region/quantitative analysis (1) Spectrophotometry/green analytical method (1) Turbidimetric method/quality control/validation (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2015 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última A green approach for the quantification of daptomycin in pharmaceutical formulation by UV spectrophotometry BJPS Tótoli,Eliane Gandolpho; Salgado,Hérida Regina Nunes. abstract Daptomycin is the first approved drug from a new class of antimicrobials, the cyclic lipopeptides, and is a very important antimicrobial agent in current clinical practice. Currently, there are no "green" analytical methods described in the literature to analyze the typical pharmaceutical dosage form of daptomycin. Thus, the aim of this work was to validate an environment-friendly spectrophotometric method in the UV region, for the analysis of daptomycin as a lyophilized powder. Water was used as diluent and the analyses were carried out on a spectrophotometer at 221 nm. The method met all validation requirements of the ICH guidelines, over a concentration range of 6-21 µg mL-1. A Student's t-test demonstrated that the proposed method was... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antimicrobials/quality control; Daptomycin/determination; Spectrophotometry/UV region/quantitative analysis; Spectrophotometry/green analytical method. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000400811 Development and validation of a rapid turbidimetric assay to determine the potency of norfloxacin in tablets BJPS Chierentin,Lucas; Salgado,Hérida Regina Nunes. Norfloxacin is one of the first commercially available (and most widely used) fluoroquinolone antibiotics. This paper reports the development and validation of a simple, sensitive, accurate and reproducible turbidimetric assay method to quantify norfloxacin in tablets formulations in only 4 hours. The bioassay is based on the inhibitory effect of norfloxacin upon the strain ofStaphylococcus epidermidis ATCC 12228 IAL 2150 used as test microorganism. The assay was performed 3x3 parallel lines like, three tubes for each concentration of reference substance and three tubes for each sample concentration. The results were treated statistically by analysis of variance and were found to be linear (r2 = 0.9999) in the selected range of 25-100 μg mL-1; precise... Tipo: Info:eu-repo/semantics/article Palavras-chave: Microbiological assay; Quality control; Norfloxacin/quantification in tablets; Turbidimetric method/quality control/validation; Antimicrobials/quality control. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300629 Registros recuperados: 2 Primeira ... 1 ... Última

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